Many pregnancies in cattle terminate before they hardly get started. This failure of pregnancy to proceed may occur within microseconds after fertilisation, or it might occur at any stage of pregnancy. However most losses occur in the first 2 weeks of development (for example when an embryo degenerates, Figure 1) and thus represent early pregnancy loss, or EPL.
Until recently, the causes of EPL have been poorly understood with much of it assumed to be inevitable. However, this assumption is being challenged today on several fronts. To better understand what might be preventable, we first need to look at the different factors which can contribute to loss. These can be discussed as follows:
Genetic/Coding Anomalies
This category includes chromosome problems (e.g. number, structure or poor pairing) which can lead to early termination of pregnancy. However, this probably occurs less often than commonly thought. On the other hand, disturbances of DNA integrity or packaging are increasingly implicated in EPL as discussed below.
Stress
Although physical and/or psychological stress can lead to infertility via disruption of those hormones causing heat and ovulation, they very rarely cause EPL. Despite this, heat stress definitely plays a role. Here, research from Florida showed there are two critical periods for heat stress (measured by the temperature-humidity index) to cause damage: just after fertilisation, and at the time of implantation (approximately 2 weeks after breeding).
Many pregnancies in cattle terminate before they hardly get started. This failure of pregnancy to proceed may occur within microseconds after fertilisation, or it might occur at any stage of pregnancy. However most losses occur in the first 2 weeks of development (for example when an embryo degenerates, Figure 1) and thus represent early pregnancy loss, or EPL.
Until recently, the causes of EPL have been poorly understood with much of it assumed to be inevitable. However, this assumption is being challenged today on several fronts. To better understand what might be preventable, we first need to look at the different factors which can contribute to loss. These can be discussed as follows:
Genetic/Coding Anomalies
This category includes chromosome problems (e.g. number, structure or poor pairing) which can lead to early termination of pregnancy. However, this probably occurs less often than commonly thought. On the other hand, disturbances of DNA integrity or packaging are increasingly implicated in EPL as discussed below.
Stress
Although physical and/or psychological stress can lead to infertility via disruption of those hormones causing heat and ovulation, they very rarely cause EPL. Despite this, heat stress definitely plays a role. Here, research from Florida showed there are two critical periods for heat stress (measured by the temperature-humidity index) to cause damage: just after fertilisation, and at the time of implantation (approximately 2 weeks after breeding).
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